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The guideline explicitly states: "Clinicians should screen for depression, anxiety, and disordered eating behaviors before initiating and during pharmacotherapy for obesity in adolescents" [19]

Currently, it is believed that CB1R is primarily associated with promoting the production of inflammatory mediators, while CB2R is mainly involved in inhibiting inflammation, thereby communicating with immune cells (154)

Tyrosinase is an enzyme that is involved in the production of melanin, and glutathione has been shown to inhibit the activity of tyrosinase, which can help to reduce the production of melanin

demonstrated that LDHA is overexpressed in pancreatic cancer tissues and upregulated under hypoxia via HIF-1/2 binding to its promoter