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Following clinical guidelines with reasonable eligibility checks We observed significant variability in the thoroughness of clinical evaluations and the clarity of treatment eligibility criteria

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However, the remarkably high rate of favorable responses we have seen from ad hoc use of such drugs in the cases presented here of MCAS, often in association with obesity which has been resistant/refractory to multiple lines of other MCAS-targeting treatments, strongly suggests such drugs have strong potential to help in at least some of the more severe cases of MCAS, the studys authors said