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Removing triggers remains essential, even with GLP-1 therapy
Additional risks specific to the bodybuilding context include: Cardiovascular strain: Increases in resting heart rate have been observed with GLP-1 receptor agonists as a class (as documented in the Summary of Product Characteristics for licensed agents such as semaglutide and tirzepatide)
A drastic reduction in the life span of cystatin C L68Q carriers due to life-style changes during the last two centuries
Despite these benefits, clinicians should be aware of specific considerations
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