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In a population pharmacokinetic analysis of plasma dofetilide concentrations, the mean dofetilide clearance of dofetilide was 16% lower in patients on thiazide diuretics
Further proteomic analysis revealed that myddosomes include proteins participating in every stage of the TLR pathway and regulate diverse effector responses
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This suggests that ED is not a common or known side effect in the general population using the drug
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