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P., Singh, S

According to the Endocrine Society's 2024 clinical practice guideline on pharmacological management of obesity, tirzepatide is recommended as a first-line pharmacotherapy option for adults with obesity, with the Society explicitly noting that step therapy requirements "may delay access to the most effective available agents." This guideline gives prescribers evidence-based ammunition when challenging step therapy mandates

Drug Interactions 7.1 Concomitant Use with Insulin or an Insulin Secretagogue (e.g., Sulfonylurea) ZEPBOUND lowers blood glucose

This has led to increased interest in whether weight loss injections can be used alongside thyroid hormone replacement therapy