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What This Means Practically For someone weighing 220 pounds: On Trulicity (maximum dose): Expected loss: 7-11 pounds End weight: 209-213 pounds On Ozempic (maximum diabetes dose): Expected loss: 15-18 pounds End weight: 202-205 pounds On Wegovy (weight loss dose): Expected loss: 33 pounds End weight: 187 pounds The difference between Trulicity and higher-dose semaglutide is substantial for patients with significant weight to lose

However, because only five studies were included and we observed considerable uncertainty in the heterogeneity estimate, the reported low value should not be interpreted as evidence of homogeneity

Austin, K., Markovic, M

Chiao EY, Krown SE