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In Phase 3 TRIUMPH-1 (May 21, 2026), the 12 mg arm averaged 28.3% weight loss at 80 weeks, and a higher-BMI subgroup reached 30.3% at 104 weeks

Analysis of candidate cis-regulatory elements (cCREs) has shown that some diabetes-associated variants reduce chromatin accessibility at binding sites for transcription factors such as HNF1A and HNF4A, thereby impairing maintenance of a functional phenotype (Wang et al., 2023)