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In addition, the activation of GLP-1R results in a cascade that activates adenyl cyclase via G s , resulting in an increased secretion of cyclic adenosine monophosphate (cAMP) secretion and activating cAMP-dependent protein kinase (PKA)
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Nitric oxide (NO) is a free radical gas molecule produced endogenously from L-arginine, oxygen, and NADPH by an enzyme nitric oxide synthase (NOS) [139]
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