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A retatrutida descrita como triplo agonista porque atua simultaneamente em trs receptores hormonais que regulam o metabolismo: GLP1 (peptdeo semelhante ao glucagon-1) estimula a produo de insulina, retarda o esvaziamento gstrico e aumenta a saciedade, contribuindo para a reduo do apetite

Animal studies have demonstrated that GLP-1 receptor agonists can increase sympathetic nerve activity, particularly to the heart and kidneys

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