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Soluble fibre is particularly effective as gut bacteria ferment it into short-chain fatty acids that directly trigger GLP-1 release from intestinal L-cells

Source: Barrett, et al JAMA Surgery, September 17, 2025 Researchers correlated insurance claims data and electronic medical records in a system that owns both an insurance plan (Highmark) and a provider system (Allegheny Health), and compared total medical expense for over 30,000 individuals who had either metabolic and bariatric surgery (sleeve gastrectomy) or were treated with GLP-1 medications between 2018 and 2023

SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization