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But when exposure to triggers becomes chronic, and your TLRs are continuously activated, it can cause your mast cells to become highly sensitive and over-reactive.13,14 In mast cell activation syndrome, or MCAS, chronic TLR activation creates hypersensitive mast cells that get stuck in overproduction mode setting off an inflammatory response that can spread throughout your body

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This condition can be caused by various factors, mainly from the external environment

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