The reaction is catalyzed by the carnitine acetyltransferase (CrAT, EC:2.3.1.7), which is present in many cell compartments, including the cytosol, the matrix or mitochondria and peroxisomes, as well as the endoplasmic reticulum and nucleus [5, 83, 106]
It does, however, intend to provide a practical overview of several (patho)physiological conditions in which knowledge of this interplay is important, to understand why and how metabolism responds
Starting with lower doses and gradually increasing lets you assess how well you tolerate it
The active sites of GPX5 and GPX7-GPX8 do not contain selenium cysteine (Secys), but instead, have cysteine residues (Cys) as their active sites