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Why resistance training matters Resistance training: Stimulates muscle protein synthesis Helps maintain or increase muscle mass Improves strength and physical function Studies consistently show that people who combine GLP-1 therapy with structured exercise are more likely to preserve lean mass than those who do not
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The main endogenous ligand for GLP-1R, the 29 amino acid peptide GLP-1(7-36)NH 2 , is highly susceptible to degradation by proteolytic enzymes that rapidly destroy it in the circulation, making it unsuitable as a therapeutic agent (Deacon et al., 1998)
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