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IQVIA Institute white paper, February 2026: 2 Breaking New Ground: Advancing Cancer Care with Novel Therapeutic Modalities

The CSF flow, as here quantified, is thus employed as a proxy for CSF secretion, and has repeatedly been demonstrated to be affected similarly to CSF secretion rates obtained by the ventriculo-cisternal perfusion assay by different modulators (activator/inhibitors) [36, 37, 46, 47]

Pekala, J., Patkowska-Sokola, B., Bodkowski, R., Jamroz, D., Nowakowski, P., Lochynski, S., & Librowski, T

Ramping up the dose too quickly shocks the system, leading to much more intense side effects like severe nausea and vomiting