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They're not necessarily indicators of intolerance but rather evidence of pharmacological activity
doi: 10.1038/s41419-021-03433-0 169 CallahanVHawksSCrawfordMALehmanCWMorrisonHAIvesterHMet al
The peptides you can order yourself online are overwhelmingly labeled research grade or not for human use. Those products are not regulated and carry real risk
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