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We quantified the amount of glutathione (precisely, GSH + GSSG) in cells expressing MRP1, MRP2 and chimera
It is a delivery system where glutathione is encapsulated within the aqueous core of a phospholipid vesicle
This analysis revealed no major differences in the OTA-signal between ABT pre-treatment and vehicle controls, neither in the sinusoids, nor in hepatocytes or bile canaliculi
Restriction of the substrate (homocysteine) can limit the formation of the product (glutathione)
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