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For example, simultaneous activation of parallel pathways such as MAPK/ERK by AdipoRon has been reported in various cancer models, suggesting a potential for pathway cross-talk that may influence or obscure AMPK signaling outcomes in vivo (22, 45)
All experimental procedures involving animals were conducted following international recommendations for the care and use of laboratory animals, as well as the guidelines of the Brazilian Society of Neurosciences and Behavior for Animal Care
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