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Thyroid considerations Both medications carry warnings about thyroid C-cell tumors based on animal studies
Researchers are currently investigating whether using GLP-1s leads to a higher proportion of lean mass loss, but the available evidence suggests that people who lose weight while using GLP-1s can still maintain or even improve their muscle function
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Mayo Clinics ENDO 2025 finding (tirzepatide plus HRT produces ~35% more weight loss than tirzepatide alone) is why hormonal context belongs in every program-choice conversation for women over 40
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