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Expression of HIV-1 Intron-Containing RNA in microglia induces inflammatory responses
TB-500 (5mg) is a synthetic version of a 43-amino-acid region of thymosin beta-4, a 4.9 kDa protein expressed in nearly all animal cell types
Measured HbA1c (a three-month blood-sugar marker) and body-weight change
Given that impaired autophagy and dysregulated mucin secretion are key contributors to barrier dysfunction, TB-500s regenerative and anti-inflammatory actions may indirectly support mucin2 production and mucus layer integrity, though direct evidence in colitis models remains limited
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