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In turn, metabolic reprogramming of immune cells exacerbates mitochondrial injury and metabolic dysfunction in cardiomyocytes through cytokine release, reactive oxygen species production, and accumulation of metabolic byproducts (76)
Additionally, the gel started forming within minutes of mixing, ensuring sufficient time for the injection while minimising spread at the injection site, so that the depot is small enough to be comfortable and inconspicuous
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Important to know that the studies used in the review were small scale and need to be replicated for clearer insights
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