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HPG axis central effects: hypothalamus and pituitary Evidence on the potential neuroendocrine actions of GLP-1 on HPG axis was provided by an in vitro study in a rodent hypothalamic neuronal cell line (GT1-7) that reported a dose-dependent stimulating effect of GLP-1 on GnRH release, in association with a prompt increase in the plasma LH levels following the intracerebroventricular injection of GLP-1 in male rats [34]

[One and a half] months later and I found out I was pregnant

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

This discovery led to further testing and eventual FDA approval for chronic weight management