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Based on these data, experts recommend initiating studies with a conservative daily dosage of 0.5mg and before increasing to up to 1mg and 2mg daily, depending on the subject's tolerance and response

doi: 10.3389/fcimb.2025.1610523 218 XiangZ.LiX.WangX.DengB.HeH.XuM.et al

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Any changes in bone mineral density observed during GLP-1 therapy are largely secondary effects driven by caloric deficit and accelerated weight loss rather than direct pharmacological action on skeleton

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