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The underlying pathogenesis seems to be related to an inflammatory response to foreign microcapsules due to a potential deficiency of enzymes needed to break down the poly-(d,l-lactide- co -glycolide) material into lactic and glycolic acid [58,59,60]

This compound also exhibits good central nervous system penetration and a favorable safety profile, supporting its further development as a therapeutic agent for PD (Jennings et al., 2023)

On the other hand, the intervention group received the same amount of conventional medicine, along with the same modified diet plan, but were given the avocado seed extract supplementations at a dose of 100 mg/kg of the patients individual body weight, daily, two time a day before meal, for a period of 12 weeks

If symptoms persist, temporarily pausing dose escalation or returning to a lower dose may be warranted [25]