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Secondly, for detecting the HIF transcriptional activity, a dedicated HIF1 transcriptional activity assay kit (Cayman, 10006910) was used for measuring the HIF transcriptional activity, which demonstrated that the transcriptional activity of HIF1 in IDH1 wild type GSC1 and mGSCs were significantly higher than that in GSC1 transfected with IDH1 mutant vector and IDH1 mutant mGSCs, respectively (Supplementary Fig

Another study is testing how CagriSema works over longer periods and in people with higher body weights, with results expected around the first half of 2027