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Sorli C, Harashima S-I, Tsoukas GM et al (2017) Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial

On the positive side, selective GLP-1 receptor agonism avoids the glucagon receptor-mediated hepatic glucose output and potential ketogenic effects that complicate dual agonist approaches