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They are commonly used in the treatment of type 2 diabetes and, more recently, for weight management
Moreover, it has been shown that a GLP-1R agonist attenuated ER stress by downregulating ATF-4, a biomarker of ER stress, and inhibited apoptosis in INS-1 -cells, which could improve cell survival 43
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GLP-1 medications, including semaglutide and tirzepatide, are used in medical weight management to support appetite control, satiety, and metabolic health when prescribed and monitored appropriately
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