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Glucagon-like peptide-1 receptor agonists act through the incretin receptors, which results in glucose-dependent insulin secretion and a decrease in glucagon release." Furthermore, GLP-1 receptor agonists inhibit the motility of the stomach antrum and the duodenum in addition to pyloric contraction which slows GE

This can lead to a reduction in systemic histamine levels, helping to calm unprovoked allergic responses, skin flushing, and gastrointestinal distress in MCAS patients

Other research shows the mechanism may be more closely related to berberines antioxidant activity

Skin Whitening: Used for its potential to lighten skin tone by reducing melanin production through its antioxidant properties