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Treatment with sildenafil (75 mg/kg), vitamin E (500 mg/kg), and the combination of sildenafil (75 mg/kg) and vitamin E (500 mg/kg) significantly increased the activity of these enzymes compared to the CP-treated group (P 0.05)

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By navigating the intricacies of these medications, their effects, and their interactions, we can collectively enhance patient care, optimize treatment strategies, and pave the way for a future where personalized medicine becomes the norm rather than the exception