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Notably, GLP-1RAs slow the transit time of the gastrointestinal (GI) tract and suppress appetite, which could displace nutrient intake and result in mineral and vitamin deficiencies

For any pill or supplement to work, it needs to both disintegrate (crumble into small pieces) and dissolve (combine with liquid) after its been taken

These instructions also often include details about how long does a vial of semaglutide last after opening, so reading them carefully can provide answers to common concerns about storage

By 3 months, those on exenatide had a mean reduction of 7.7 monthly headache days (from a baseline of ~ 22 days/month) compared to a 1.5 day change in the placebo arm, although the between-group difference did not reach statistical significance (exenatide: p = 0.069 within-group