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This system, responsible for the degradation of damaged and unnecessary proteins through ubiquitin-mediated mechanisms, regulates numerous fundamental cellular processes
doi: 10.1093/ndt/gfp176 4 BellomoR.KellumJ
However, about 10-15% of acetaminophen is metabolized by CYP2E1 into a toxic metabolite known as NAPQI (N-acetyl-p-benzoquinone imine).[ref] Detoxification with glutathione: NAPQI then needs to be neutralized with glutathione, which is catalyzed using the GST genes
As a strong antioxidant, glutathione helps reduce free radicals that can activate tyrosinase, the enzyme that triggers melanin production
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