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Tesamorelin is an FDA-approved synthetic GHRH analog used to reduce visceral fat in HIV-associated lipodystrophy and reliably increases GH and insulin growth factor 1 (IGF-1)
[11] [4] Preclinical studies have suggested that combining amylin receptor agonism with GLP-1based therapies produces greater reductions in food intake and body weight than either approach in isolation, and early clinical data from the CagriSema programme (cagrilintide combined with semaglutide) has provided some supporting evidence in humans
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