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Carnitine panel was abnormal in half of the patients in whom it was measured with 33% of the patients having high-esterified carnitine and 17% having low free carnitine
While it appears to be well-tolerated for treatment cycles lasting several weeks to months, the effects of continuous, prolonged use are not yet known
Controlled Administration Methods: In in vivo studies, controlled-release formulations or continuous infusion pumps can help maintain stable concentrations of KLOW, effectively bypassing issues associated with a short KLOW half life and pulsatile dosing
Avoid VYVANSE use in patients with known structural cardiac abnormalities, cardiomyopathy, serious cardiac arrhythmia, coronary artery disease, or other serious cardiac disease
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