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This is accomplished by modulating key apoptosis-regulating proteins, notably by increasing the expression of the pro-survival protein Bcl-2

However, this adverse effect did not result in an increase in cardiovascular events in dedicated randomized trials [7,8]

pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance the anticancer efficacy of etoposide on non-small cell lung cancer

These combined actions have led to interest in its relevance for research models involving cardiovascular stress and impaired circulation.(23) Further animal-based investigations have reported protective effects in models of cardiac injury