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Figure 3 In terms of the AMPK-mTOR/STAT3 pathway: Metformin can increase the AMP/ATP ratio in cells and activate AMPK, thus initiating a series of downstream metabolic and growth regulation reactions, such as the inhibition of mTOR (87)
By reducing insulin resistance, Naltrexone aids in weight loss and helps lower androgen levels in women with PCOS, reducing symptoms such as excessive hair growth and depression
Platelet reactivity varies significantly among individuals and is associated with factors such as female gender, high plasma fibrinogen levels, and genetic diversity (154)
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