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In addition, fungal laccases have been functionally expressed in Saccharomyces cerevisiae at high titers 28 , indicating that yeast provide the necessary machinery for both copper insertion and glycosylation

We have addressed the suggestions to the best of our ability and summarize the changes below, along with the original comments from the reviewers

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Rather than targeting a single receptor pathway, this advanced 12,000mcg blend unifies three distinct synthetic peptide architectures: a selective lipolytic fragment, a growth hormone-releasing hormone (GHRH) receptor agonist, and a highly selective growth hormone secretagogue receptor (GHS-R1a) agonist