The Triple Agonists The so-called triple agonists like retatrutide hit a new hierarchy of hormone receptors: GLP-1, GIP, and glucagon to reduce appetite, control blood sugar, and increase energy expenditure
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These medications, which function by slowing gastric emptying, can lead to severe, chronic digestive issues, including persistent nausea, vomiting, abdominal distention, and the need for intensive medical interventions like IV therapy or feeding tubes
GSTT1 (null) and GSTP1 (AB/BB) are additional polymorphisms related to a reduction in GST activity