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J Headache Pain 24 , 89 (2023)
These include: New formulations and delivery mechanisms Lower dose, high bioavailability innovations Blood brain barrier (BBB) penetrating designs New modalities such as ADCs and fusion proteins Routine FTO checks, composition and combination filings, and route of administration strategies will be essential to maintain advantage
While FDA-approved GLP-1 injections like Wegovy and Zepbound have demonstrated 15-20% weight loss in clinical trials, GLP-1 patches lack any peer-reviewed evidence showing they deliver therapeutic blood levels or produce meaningful weight loss
Note: After the FDA approves a medication, it tracks and reviews side effects of the drug
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