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The study compared people taking GLP-1s to people prescribed a different diabetes drug

Across the controlled trials Volek's recovery work (PMID 11788381), the 2021 recovery trial (PMID 34684429), the centenarian fatigue trial (PMID 18065594), and the trials pooled in the 2016 weight meta-analysis (PMID 27335245) L-carnitine was generally well tolerated, with adverse events that were mild and did not drive meaningful discontinuation

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Results are impressive enough that a month after the NEJM study, the American Academy of Pediatrics recommended doctors consider semaglutide, along with exercise and nutrition counseling, among the options for treating children 12 and older with obesity