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Tirzepatide combines both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)
Cooling to 0 , stirring for 30min, adding 0.5g DIC and 0.22g HOSu in portions, stirring and reacting for 12 hours at the temperature, filtering, collecting filtrate, and spin-drying the filtrate to obtain crude Boc-His (Trt) -Aib-OSu
Systemic treatment with the insulin-receptor antagonist, S961, can induce -cell-specific senescence and hyperglycemia in 28-week-old C57BL/6J mice 1,12
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