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* Correspondence: Yanqiong Guo, [email protected]
Pyridoxine also antagonizes the effects of levodopa when levodopa is used without a dopa-decarboxylase inhibitor (such as carbidopa)
The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)
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