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This omission limits pharmacological context, hinders potency normalization across studies, and constrains the prioritization of peptide leads for translational development [177, 178]
Tracking makes patterns easier to see
Although few studies have evaluated the expression of KP metabolites in postmortem samples, TDO protein expression was elevated in white matter glial cells in the anterior cingulate gyrus in samples from MDD patients [61], potentially contributing to localized neuroinflammation
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