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Meanwhile, hypoxia activates the HIF-1/PDK4 axis, which inhibits PDH activity and elevates mitochondrial membrane potential(MMP), suppressing the TCA cycle while enhancing glycolysis and lactate production, ultimately driving VSMC cell cycle progression and proliferation [86]

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Nearly all secretins (with the known exception of HxcQ of Pseudomonas aeruginosa 19 ) require additional proteins, called pilotins or accessory proteins, for their assembly