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Third, immunometabolic crosstalk in the regulation of ferroptosis highlights the pivotal role of chronic low-grade inflammation in OA pathogenesis

When two compounds share a final therapeutic outcome (tissue repair) but achieve it through different receptors and cellular intermediaries, their combination can produce effects that exceed what either compound delivers alone without requiring dose escalation of either component

DOI: 10.3390/jcm9020321), researchers compared LCMS/MS, GCMS, and NMR methods for ketone body quantification in plasma samples from individuals with type 2 diabetes mellitus (T2DM)