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Un estudio in vitro de 2025 reprodujo el alargamiento telomrico en fibroblastos y clulas epiteliales normales por la va hTERT/telomerasa, y report que en lneas de clulas cancerosas la extensin telomrica ocurri en cambio a travs del mecanismo de Alargamiento Alternativo de Telmeros (ALT) , pese a la regulacin al alza de hTERT (PMID 40908429)