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Major classes of ADP-ribosyltransferases include: (1) glycohydrolases (NADases that break nucleotides into nucleosides and phosphate) (2) ADP-ribosylases (ADP-ribosylation that add one or more ADP-ribose moieties to a protein), and (3) deacetylases (deacetylations that remove an acetyl group)
However, studies indicate that metformin for adolescents may increase the incidence of mild to severe gastrointestinal side effects, such as nausea, vomiting, diarrhea, and flatulence
It is abundant in human skeletal muscle, brain, and heart
10.1155/2015/686239 180 YangD.XuK.WangW.ChenP.LiuC.LiuS.et al (2024)
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