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The cytosolic GST isoenzymes have been classified into four evolutionary classes

Primarily in the intestines, we house an estimated 38 trillion microbes (Sender et al., 2016), among which at least 2,172 known species (Hugon et al., 2015), comprising about as many (small) microbial cells as we have (large) human ones (Sender et al., 2016)

48 The reduction could also be caused by loss of aminotransferases by filtration during hemodialysis or high lactate serum levels with consumption of NADPH resulting in subnormal aminotransferase levels

Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme