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It is expressed on the cell surface of various cell types including endothelial and immune cells and in tissues like the liver and kidney

Most people get enough vitamin B12 from eating a balanced diet

Consequently, regarding the formation of multidrug resistance in tumor cells, besides acting as a detoxification enzyme though excretion of drugs to decrease pharmacological efficacy, GST can also act as an MAPK-pathway inhibitor to improve tumor-cell survival