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Tirzepatide can be used as monotherapy or in combination with other diabetes medications, such as sulfonylureas, SGLT2 inhibitors, or metformin
In pancreatic beta cells, GLP-1RA promotes the conversion of proinsulin to mature insulin by upregulating the expression of hormone converting enzymes PC1/3 and PC2, while reducing the proinsulin/insulin ratio and enhancing insulin biological activity
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