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(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)

By targeting multiple metabolic pathways, Retatrutide offers a more comprehensive approach to managing obesity than single- or dual-agonist therapies

This hormone plays a key role in managing blood sugar, insulin production, andyou guessed itappetite

This dual action is what separates it from semaglutide and other single-receptor medications