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Front Neurosci (2019) 13:1112

There was no difference in the (low) numbers of confirmed hypoglycemia between DPP-4 inhibition and placebo and the occurrence of adverse events did not differ between the study groups except a slight increase in gastrointestinal adverse events in one of the studies ( Figure 7 Placebo-Controlled Studies With DPP-4 Inhibition as Add-on to Ongoing Metformin Therapy The DPP-4 inhibitors were also examined as add-on to on-going metformin in subjects with type 2 diabetes in 2426 week studies with a total number of 3,216 subjects [Table 2

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